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The experience of pain and emergent osteoarthritis of the knee

1 Department of Pharmaceutical Health Services Research, University of Maryland, Baltimore, Baltimore, MD, United States; 2 Departments of Pharmaceutical Health Services Research and Psychiatry, University of Maryland, Baltimore, Baltimore, MD, United States; 3 Departments of Psychiatry and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, United States



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Warfarin interacts with many conventional drug products and herbal products,1-3 Given the incompleteness of information on drug-herbal product interactions and the potential for health care practitioners to be unaware of their patients' utilization of herbal products, we surveyed the use of such products among patients receiving warfarin



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The experience of pain and emergent osteoarthritis of the knee

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Vitamin C in high doses appears to interfere with the blood thinning effects of warfarin by lowering prothrombin time.33, 34, 71 Warfarin may increase the risk of bleeding if taken with niacin. 32 Increased risk of vitamin A toxicity may occur with warfarin. 32 Vitamin E may increase the risk of bleeding with warfarin.32, 33, 34, 72

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Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation (K from Koagulation, German for "coagulation") and which the body also needs for controlling binding of calcium in bones and other tissues. The vitamin K-related

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